Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases
نویسندگان
چکیده
منابع مشابه
Matrix metalloproteinases in kidney homeostasis and diseases.
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that have been increasingly linked to both normal physiology and abnormal pathology in the kidney. Collectively able to degrade all components of the extracellular matrix, MMPs were originally thought to antagonize the development of fibrotic diseases solely through digestion of excessive matrix. However, increasing ...
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Matrix metalloproteinase-7 (MMP-7) is a secreted zinc- and calcium-dependent endopeptidase that degrades a broad range of extracellular matrix substrates and additional substrates. MMP-7 playsa crucial role in a diverse array of cellular processes and appears to be a key regulator of fibrosis in several diseases, including pulmonary fibrosis, liver fibrosis, and cystic fibrosis. In particular, ...
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ژورنال
عنوان ژورنال: World Journal of Nephrology
سال: 2013
ISSN: 2220-6124
DOI: 10.5527/wjn.v2.i3.84